研究内容
脳の形態形成と機能を細胞生物的な視点から理解することを目指す
主に発生期の脳を対象として、細胞生物学の各分野の垣根をこえた統合的な視点から、個体レベルの研究（In vivo 細胞生物学）を推進していきます
[主要な研究テーマ]
- 大脳皮質形成における神経細胞の移動と樹状突起形成のメカニズムの解明
- エンドサイトーシス経路（エンドソーム／リソソーム／ゴルジ体）の生理的役割の理解
- 低分子量G蛋白質・キナーゼカスケードなどによる細胞接着と細胞骨格の制御機構
- 増殖停止細胞（神経細胞）における細胞周期関連分子の新たな機能の解明
- 神経発生における糖鎖修飾の役割の同定
主要論文（全業績は"Publication"を参照）
- Shikanai M, Nishimura YV, Sakurai M, Nabeshima YI, Yuzaki M, * Kawauchi T.
"Caveolin-1 promotes early neuronal maturation via caveolae-independent trafficking of N-cadherin and L1" iScience (2018) Vol.7, 53-67. - Nishimura YV, Shikanai M, Hoshino M, Ohshima T, Nabeshima YI, Mizutani K, Nagata K, Nakajima K, * Kawauchi T.
"Cdk5 and its substrates, DCX and p27kip1, regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons" Development (2014) Vol.141 (18) 3540-3550. - Sekine K, Kawauchi T, Kubo K, Honda T, Herz J, Hattori M, Kinashi T, Nakajima K.
"Reelin controls neuronal positioning by promoting cell-matrix adhesion via inside-out activation of integrin alpha5beta1" Neuron (2012) Vol.76 (2) 353-369. - * Kawauchi T, Sekine K, Shikanai M, Chihama K, Tomita K, Kubo K, Nakajima K, Nabeshima YI, Hoshino M.
"Rab GTPases-dependent endocytic pathways regulate neuronal migration and maturation through N-Cadherin trafficking" Neuron (2010) Vol.67 (4) 588-602. - Nishimura YV, Sekine K, Chihama K, Nakajima K, Hoshino M, Nabeshima YI, * Kawauchi T.
"Dissecting the factors involved in the locomotion mode of neuronal migration in the developing cerebral cortex" J Biol Chem (2010) Vol.285 (8) 5878-5887. - Kawauchi T, Chihama K, Nabeshima YI, Hoshino M.
"Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration" Nature Cell Biol (2006) Vol.8 (1) 17-26. - Hoshino M, Nakamura S, Mori K, Kawauchi T, Terao M, Nishimura YV, Fukuda A, Fuse T, Matsuo N, Sone M, Watanabe M, Bito H, Terashima T, Wright CVE, Kawaguchi Y, Nakao K, Nabeshima YI.
"Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum" Neuron (2005) Vol.47, 201-213. - Kawauchi T, Chihama K, Nishimura YV, Nabeshima YI, Hoshino M.
"MAP1B phosphorylation is differentially regulated by Cdk5/p35, Cdk5/p25 and JNK" Biochem Biophys Res Commun (2005) Vol.331 (1) 50-55. - Yoshizawa M, Kawauchi T, Sone M, Nishimura YV, Terao M, Chihama K, Nabeshima YI, Hoshino M.
"Involvement of a Rac activator, P-Rex1, in neurotrophin-derived signaling and neuronal migration" J Neurosci (2005) Vol.25 (17) 4406-4419. - Kawauchi T, Chihama K, Nabeshima YI, Hoshino M.
"The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration" EMBO J (2003) Vol.22 (16) 4190-4201. - Kawauchi T, Ikeya M, Takada S, Ueda K, Shirai M, Takihara Y, Kioka N, Amachi T.
"Expression of vinexin alpha in the dorsal half of the eye and in the cardiac outflow tract and atrioventricular canal" Mech Dev (2001) Vol.106 (1-2) 147-150. - Kioka N, Sakata S, Kawauchi T, Amachi T, Akiyama SK, Okazaki K, Yaen C, Yamada KM, Aota S.
"Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization" J Cell Biol (1999) Vol.144 (1) 59-69.
( *: corresponding author )
(平均被引用数 = 71.4, 総被引用数 ＝ 2357)
(2018年9月12日現在, Google Scholarより)
主要論文（英文総説）
- * Kawauchi T. "Tubulin isotype specificity in neuronal migration: Tuba8 can’t fill in for Tuba1a" J Cell Biol (2017) Vol.216 (8) 2247-2249.
- * Kawauchi T. "Cellular insights into cerebral cortical development: focusing on the locomotion mode of neuronal migration" Front Cell Neurosci (2015) Vol.9, 394.
- * Kawauchi T.
"Cdk5 regulates multiple cellular events in neural development, function and disease" Dev Growth Differ (2014) Vol.56 (5) 335-348. - * Kawauchi T, Shikanai M, Kosodo Y.
"The extra-cell cycle regulatory functions of CDK proteins and CDK inhibitors contribute to brain development and neurological disorders" Genes Cells (2013) Vol.18 (3) 176-194. - * Kawauchi T.
"Cell adhesion and its endocytic regulation in cell migration during neural development and cancer metastasis" Int J Mol Sci (2012) Vol.13 (4) 4564-4590. - * Kawauchi T, Hoshino M.
"Molecular Pathways Regulating Cytoskeletal Organization and Morphological Changes in Migrating Neurons" Dev Neurosci (2008) Vol.30 (1-3) 36-46.
( *: corresponding author )
所属学会
日本神経科学会・日本細胞生物学会・日本生化学会・日本神経化学会・日本分子生物学会・Society for Neuroscience (北米神経科学会)
委員会など
日本生化学会：「生化学」誌 企画委員（2014-現在）
日本神経化学会：シンポジウム企画委員（2013-2014）
日本神経化学会：出版・広報委員（2017-現在）
日本細胞生物学会：代議員（2015-2016）
文部科学省 科学技術政策研究所 科学技術動向研究センター：専門調査員 （平成26年度-現在）